Agressive types of breast cancer

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Added: 12.02.2021
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Chemotherapy chemo uses anti-cancer drugs that may be given intravenously injected into your vein or by mouth. The drugs travel through the bloodstream to reach cancer cells in most parts of the body. Occasionally, chemo may be given directly into the spinal fluid which surrounds the brain and spinal cord. Not all women with breast cancer will need chemo, but there are several situations in which chemo may be recommended:. For certain types of breast cancer, if there are tumor cells still found at the time of surgery also called residual disease , you may be offered more chemotherapy after surgery to reduce the chances of the cancer coming back recurrence.
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Rare types of breast cancer | Breast Cancer | Cancer Research UK

Vanderbilt-Ingram Cancer Center researchers have identified six subtypes of an aggressive and difficult-to-treat form of breast cancer, called triple-negative breast cancer TNBC. In the July issue of the Journal of Clinical Investigation , Cancer Center Director Jennifer Pietenpol , and colleagues describe the molecular features of these six distinct subtypes and identify chemotherapies to which the different subtypes respond in cultured cells and animal tumor models. Knowing the specific subtype could help physicians determine which therapies would work best in patients with TNBC and also inform the discovery and development of new drugs to treat this form of breast cancer, the authors suggest. TNBCs account for 10 percent to 20 percent of all breast cancers and tend to be more aggressive than other types of breast cancer. While some patients with TNBC initially respond well to standard chemotherapy, these tumors are more likely to recur after treatment and have a poorer prognosis. Less than 30 percent of women with metastatic TNBC — which has spread outside the breast — survive five years. They also show no amplification of another receptor, called HER2, which drives about 20 percent to 30 percent of breast cancers.
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Different types of aggressive breast cancer identified

Tumor grade is the description of a tumor based on how abnormal the tumor cells and the tumor tissue look under a microscope. It is an indicator of how quickly a tumor is likely to grow and spread. The factors used to determine tumor grade can vary between different types of cancer. Tumor grade is not the same as the stage of a cancer. Cancer stage is based on factors such as the location of the primary tumor , tumor size, regional lymph node involvement the spread of cancer to nearby lymph nodes , and the number of tumors present.
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Inflammatory breast cancer is a rare and very aggressive disease in which cancer cells block lymph vessels in the skin of the breast. Inflammatory breast cancer is rare, accounting for 1 to 5 percent of all breast cancers diagnosed in the United States. Most inflammatory breast cancers are invasive ductal carcinomas, which means they developed from cells that line the milk ducts of the breast and then spread beyond the ducts. Inflammatory breast cancer progresses rapidly, often in a matter of weeks or months. At diagnosis, inflammatory breast cancer is either stage III or IV disease, depending on whether cancer cells have spread only to nearby lymph nodes or to other tissues as well.
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